Continuing on from the "Save Shaundi" ending to Saints Row: The Third, the Saints are called to assist MI-6 agent Asha Odekar and her associate Matt Miller, the former Deckers leader. The Saints rescue America from a nuclear missile launched by Cyrus Temple, the former STAG leader, who has gone insane and is obsessed with killing the Saints. After killing Cyrus and saving America from the missile hitting Washington, the Presidency of the United States is unlocked.
5 years later after the events of saving America. The Babe is now the President of the United States and is able to make decisions to cure cancer or end world hunger, punch a man in the nads or the head and decide to either decline or accept Josh Birk's offer to watch Nyte Blayde with Oleg. As Shaundi warns The Babe about an attack, the Earth is invaded by the Zin Empire, an alien race led by Emperor Zinyak. The Babe is captured by the Zin along with her cabinet and placed in a virtual simulation of Steelport, and must escape in order to have any hope of saving the Earth.
The Babe is then placed in a 50s sitcom simulation in the city of Steelport where violence and foul language are prohibited. Kinzie contacts the babe and helps them escape the simulation by Zinyak, being brought to a new one which is Steelport run by Zinyak. In the simulation, Kinzie is able to find clusters left around in Steelport and are able to gain super powers. With Kinzie's help, The Babe is able to go through a door to their real body, which is imprisoned on Zinyak's ship. They then meet Kinzie and Vice President Keith David who rescue The Babe. As the Saints try to contact reinforcements from Earth, Zinyak destroys the planet and kills everybody who was not already captured by the Zin. The Babe vows to get revenge for Earth and to return to the simulation to disrupt it to kill Zinyak. The Babe goes to save their other teammates from their simulations revealing their worst fears. Matt Miller's being stuck in a cyberworld with Killbane trying to kill him, Shaundi's past, calm, fun-loving self, Pierce's fear of the Saints image turning on him, Benjamin King's fear of his former gang members; the Vice Kings killing him and Asha's fear of failing a mission...
Movie Chapters:
Purple Ops (Zero Saints Thirty): 00:00; Hail to the Chief (The Saints Wing): 13:16; Leave it to the Saints (A Pleasant Day): 25:12; Learn the Rules...: 35:40; Hot and Cold: 45:36; The Escape (The Real World): 58:05; Breaking the Law (Hack the Planet): 1:14:08; CID (Ghost in the Machine): 1:18:38; Miller Space (Break Matt Miller Out): 1:49:44; Matt's Back (Retrieve Matt Miller): 2:08:46; Back by Popular Demand (De Plane Boss): Save Shaundi and Fun Shaundi: 2:25:27; Nytefall (Join Matt's Adventure): 2:36:45; Girls Night Out (Psychosomatic): Help The Shaundis With Their Issues: 2:47:41; The Boss Goes to Washington (The Saints Flow): Rescue Pierce: 3:01:57; Pump Up the Volume (Brotherhood): Follow Pierce's Plan: 3:12:37;
King of Stilwater (King Me): Rescue Ben King: 3:25:45; King of the Dance (Dancing Queen): Finish Off Tanya: 3:39:08; From Asha with Love (The Case of Mr. X): Rescue Asha: 3:51:26; Training Day (Asha's VIP): Help Out Asha: 4:12:14; ...the Very Next Day (Welcome Back): Rescue Johnny Gat: 4:23:32; 4:49:28; SR3 Wrap-up (Gat Time, Fun Time): Spend Quality Time with Gat: 4:49:28; The Kinzie Gambit: 5:04:26; He Lives: Locate Keith David: 5:30:43; The Girl Who Hates the 50s (Hello Teacup): Rescue Kinzie: 5:44:59; The Girl Who Beat Cyrus (Kinzie's Adventures): Finish Off Cyrus: 5:57:56;
Keymaster (We have the Technology): Collect Parts for the Key: 6:04:26; Keymaster (Batteries Not Included): Finish the Key: 6:16:56; Grand Finale: 6:32:11.
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