Argonne National Laboratory is one of the United States Department of Energy's oldest and largest science and engineering research national laboratories and is the largest in size in the Midwest. It is located on 1,700 acres (6.9 km²) in DuPage County, 25 miles (40 km) southwest of Chicago, Illinois, on Interstate 55, completely encircled by Waterfall Glen Forest Preserve.

Argonne conducts basic and applied research in energy storage, alternative energy and efficiency, nuclear energy, national security, and biological and environmental systems. Argonne's scientific user facilities, such as the Advanced Photon Source, the Center for Nanoscale Materials, ATLAS, and the Argonne Leadership Computing Facility, help advance America's scientific leadership and prepare the nation for the future.

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Argonne National Laboratory is the first science and engineering national laboratory in the U.S., addressing challenges in energy, environment and security.