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Welcome to the swinging sixties. In Season 3 of Masters of Sex, thrust into the spotlight by the publication of their controversial study, Dr. William Masters (Michael Sheen) and Virginia Johnson (Lizzy Caplan) find themselves the unlikely leaders of the sexual revolution. But as newfound fame and pressures mount, their relationship becomes twisted and tangled putting the couple in a position that even they might not be able to handle.
In Season 2 of Masters of Sex, Dr. William Masters (Michael Sheen) and Virginia Johnson (Lizzy Caplan) struggle to get their work back on track while taking their relationship to a much more intimate place; Libby (Caitlin FitzGerald) flounders in a loveless marriage and turns to volunteering; Former prostitute Betty DiMello (Annaleigh Ashford) tries for the American dream; Dr. Austin Langham (Teddy Sears) becomes the spokesman for a popular diet company and the boy toy to its aggressive founder.
Season 1 of Masters of Sex - In 1956, former nightclub singer and single mother Virginia Johnson (Lizzy Caplan) becomes the assistant to renowned OBGYN William Masters (Michael Sheen). They embark on their pioneering study in human sexuality while trying to navigate their personal feelings for each other. Masters' wife Libby (Caitlin FitzGerald) tries to conceive a child to save her marriage. Dr. Ethan Haas (Nicholas D'Agosto) chafes under the supervision of Dr. Masters and deals with a changing society. University Provost Barton Scully (Beau Bridges) struggles to support his protege William Masters while dealing with a long-held personal secret.